Large changes in infrastructure shift categories, memberships, and the nature of personhood.  Some of these shifts include the creation of non-people via the rise of residual categories.  For instance, the widespread adoption of networked computing produced the category of "non-users"; the rise of an interlinked biomedical system produced the category "non-compliant."  This talks examines how the inhabitants of residual categories become orphans of infrastructure -- invisible others -- and the consequences of such changes.